Medicinal mushrooms are reported to have antimicrobial, anti-inflammatory, cardiovascular-protective, antidiabetic, hepatoprotective, and anticancer properties. It is well-established that mushrooms are adept at immune modulation and affect immature red blood cells, lymphocytes, macrophages, T cells, dendritic cells (DCs), and natural killer (NK) cells. All that medical jargon aside, the bottomline is that both reishi and maitake have been used extensively in cancer treatment in humans and mice.