Medicinal mushrooms are reported to have antimicrobial, anti-inflammatory, cardiovascular-protective, antidiabetic, hepatoprotective, and anticancer properties. It is well-established that mushrooms are adept at immune modulation and affect immature red blood cells, lymphocytes, macrophages, T cells, dendritic cells (DCs), and natural killer (NK) cells. All that medical jargon aside, the bottomline is that both reishi and maitake have been used extensively in cancer treatment in humans and mice.Shiitake is another medicinal with a bunch of benefits - in medical jargon: antiproliferative, immunostimulatory, hepatoprotective, and antimutagenic! There have also been anti-tooth decay effects in vitro and in mice. Lentinan, a carb (polysaccharide) isolated from shiitake, has been well studied and is thought responsible for the mushroom’s beneficial effects. It’s been shown to improve immunity, as seen by improved cell proliferation and activation and increased sIgA (secretory immunoglobulin A) production, in humans.